OrangerV1, France, Analysis, bibRecord, 000116

Citrus Fruit Extracts Reduce Advanced Glycation End Products (AGEs)- and H2O2-Induced Oxidative Stress in Human Adipocytes

Identifieur interne : 000116 ( France/Analysis ); précédent : 000115; suivant : 000117

Citrus Fruit Extracts Reduce Advanced Glycation End Products (AGEs)- and H2O2-Induced Oxidative Stress in Human Adipocytes

Auteurs : Deena Ramful [Maurice (pays)] ; Evelyne Tarnus [France] ; Philippe Rondeau [France] ; Christine Robert Da Silva [France] ; Theeshan Bahorun [Maurice (pays)] ; Emmanuel Bourdon [France]

Source :

Journal of agricultural and food chemistry : (Print) [ 0021-8561 ] ; 2010.

RBID : Pascal:10-0502647

Descripteurs français

Pascal (Inist)
- Agrume, Extrait, Glycation, Age, Stress oxydatif, Homme, Adipocyte, Antioxydant, Cellule.
Wicri :
- topic : Agrume, Homme.

English descriptors

KwdEn :
- Adipocyte, Adipocytes (drug effects), Adipocytes (metabolism), Age, Antioxidant, Antioxidants (pharmacology), Cell, Citrus (chemistry), Citrus fruit, Down-Regulation (drug effects), Extract, Fruit (chemistry), Glycation, Glycosylation End Products, Advanced (metabolism), Human, Humans, Hydrogen Peroxide (adverse effects), Oxidative Stress (drug effects), Oxidative stress, Plant Extracts (pharmacology).
MESH :
- chemical , adverse effects : Hydrogen Peroxide.
- chemical , metabolism : Glycosylation End Products, Advanced.
- chemical , pharmacology : Antioxidants, Plant Extracts.
- chemistry : Citrus, Fruit.
- drug effects : Adipocytes, Down-Regulation, Oxidative Stress.
- metabolism : Adipocytes.
- Humans.

Abstract

Diabetes is a reactive oxygen species (ROS)-mediated pathology, with a worldwide prevalence estimated to double by 2030. A major effort has been launched to find therapeutic means to improve health conditions of diabetic patients. Recent data show that supplemental natural antioxidants represent a potential strategy as adjunct therapy. Despite the major role of adipocytes in the etiology of diabetes, little is known about the effect of natural antioxidants on adipocyte response to oxidative stress. Using a diabetes-like oxidative stress model, the potential protective effect of antioxidative flavedo, albedo, and pulp extracts of (1) tangor Elendale (Citrus rehculata × Citrus sinensis) and (2) tangelo Minneola (C. reticulata x Citrus paradisis) was investigated on human adipocytes. Besides the retardation of free-radical-induced hemolysis of human erythrocytes, non-cytotoxic concentrations of tangelo and tangor flavedo extracts significantly reduced the levels of protein carbonyls in response to advanced glycation end products (AGEs) generated by albumin glycation in SW872 cells. Flavedo extracts lowered carbonyl accumulation in H₂O₂-treated adipocytes, while tangelo and tangor flavedo, albedo, and pulp extracts suppressed ROS production in SW872 cells with or without the addition of H₂O₂. Our results clearly show that Mauritian Citrus fruit extracts represent an important source of antioxidants, with a novel antioxidative role at the adipose tissue level.

Url:

http://hal.univ-reunion.fr/hal-01198347

Affiliations:

France, Maurice (pays)

Links to Exploration step

Pascal:10-0502647

Le document en format XML

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-Induced Oxidative Stress in Human Adipocytes</title>
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-Induced Oxidative Stress in Human Adipocytes</title>
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<front><div type="abstract" xml:lang="en">Diabetes is a reactive oxygen species (ROS)-mediated pathology, with a worldwide prevalence estimated to double by 2030. A major effort has been launched to find therapeutic means to improve health conditions of diabetic patients. Recent data show that supplemental natural antioxidants represent a potential strategy as adjunct therapy. Despite the major role of adipocytes in the etiology of diabetes, little is known about the effect of natural antioxidants on adipocyte response to oxidative stress. Using a diabetes-like oxidative stress model, the potential protective effect of antioxidative flavedo, albedo, and pulp extracts of (1) tangor Elendale (Citrus rehculata × Citrus sinensis) and (2) tangelo Minneola (C. reticulata x Citrus paradisis) was investigated on human adipocytes. Besides the retardation of free-radical-induced hemolysis of human erythrocytes, non-cytotoxic concentrations of tangelo and tangor flavedo extracts significantly reduced the levels of protein carbonyls in response to advanced glycation end products (AGEs) generated by albumin glycation in SW872 cells. Flavedo extracts lowered carbonyl accumulation in H<sub>2</sub>
O<sub>2</sub>
-treated adipocytes, while tangelo and tangor flavedo, albedo, and pulp extracts suppressed ROS production in SW872 cells with or without the addition of H<sub>2</sub>
O<sub>2</sub>
. Our results clearly show that Mauritian Citrus fruit extracts represent an important source of antioxidants, with a novel antioxidative role at the adipose tissue level.</div>
</front>
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Citrus Fruit Extracts Reduce Advanced Glycation End Products (AGEs)- and H2O2-Induced Oxidative Stress in Human Adipocytes

Citrus Fruit Extracts Reduce Advanced Glycation End Products (AGEs)- and H2O2-Induced Oxidative Stress in Human Adipocytes

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Descripteurs français

English descriptors

Abstract

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